Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer
Identifieur interne : 006794 ( Main/Exploration ); précédent : 006793; suivant : 006795Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer
Auteurs : C. K. Lee [Australie] ; R. J. Simes [Australie] ; C. Brown [Australie] ; S. Lord [Australie] ; U. Wagner [Allemagne] ; M. Plante [Canada] ; I. Vergote [Belgique] ; C. Pisano [Italie] ; G. Parma [Italie] ; A. Burges [Allemagne] ; H. Bourgeois [France] ; T. Högberg [Suède] ; J. Bentley [Canada] ; L. Angleitner-Boubenizek [Autriche] ; A. Ferrero [Italie] ; B. Richter [Allemagne] ; H. Hirte [Canada] ; V. Gebski [Australie] ; J. Pfisterer [Allemagne] ; E. Pujade-Lauraine [France] ; M. Friedlander [Australie]Source :
- British journal of cancer [ 0007-0920 ] ; 2011.
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Abstract
BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy. METHODS: The nomogram was developed in a training cohort (n=955) from the CALYPSO trial and validated in the AGO-OVAR 2.5 Study (n = 340). The proportional-hazards model (nomogram) was based on pre-treatment characteristics. RESULTS: The nomogram had a concordance index (C-index) of 0.645. Significant predictors were tumour size platinum-chemotherapy-free interval, CA-125, number of organ metastatic sites and white blood count. When the nomogram was applied without CA-125 (CA-125 was not available in validation cohort), the C-indices were 0.624 (training) and 0.594 (validation). When classification was based only on the platinum-chemotherapy-free interval, the indices were 0.571 (training) and 0.560 (validation). The calibration plot in the validation cohort based on four predictors (without CA-125) suggested good agreement between actual and nomogram-predicted 12-month PFS probabilities. CONCLUSION This nomogram, using five pre-treatment characteristics, improves prediction of PFS in patients with platinum-sensitive ovarian cancer having platinum-based chemotherapy. It will be useful for the design and stratifcation of patients in clinical trials and also for counselling patients.
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Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, France, Italie, Suède
- Bavière, District de Dresde, District de Haute-Bavière, Lombardie, Nouvelle-Galles du Sud, Piémont, Province du Brabant flamand, Saxe (Land), Île-de-France
- Dresde, Louvain, Milan, Munich, Paris, Sydney, Turin
- Université Paris-Descartes, Université de Sydney
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Bourgeois</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Onco-Hematology, Centre Jean Bernard - SARL SORECOH, 9 Rue Beauverger</s1><s2>72000 Le Mans</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>72000 Le Mans</wicri:noRegion><wicri:noRegion>9 Rue Beauverger</wicri:noRegion><wicri:noRegion>72000 Le Mans</wicri:noRegion></affiliation></author><author><name sortKey="Hogberg, T" sort="Hogberg, T" uniqKey="Hogberg T" first="T." last="Högberg">T. Högberg</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Gynaecologic Oncology, Linkjoping University Hospital</s1><s2>Linkjoping</s2><s3>SWE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Linkjoping</wicri:noRegion></affiliation></author><author><name sortKey="Bentley, J" sort="Bentley, J" uniqKey="Bentley J" first="J." last="Bentley">J. Bentley</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Dalhousie University, 5820 University Avenue</s1><s2>Halifax, Nova Scotia,B3H IV7</s2><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Halifax, Nova Scotia,B3H IV7</wicri:noRegion></affiliation></author><author><name sortKey="Angleitner Boubenizek, L" sort="Angleitner Boubenizek, L" uniqKey="Angleitner Boubenizek L" first="L." last="Angleitner-Boubenizek">L. Angleitner-Boubenizek</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>BHS Linz, Seilerstätte 4</s1><s2>4020 Linz</s2><s3>AUT</s3><sZ>14 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>4020 Linz</wicri:noRegion></affiliation></author><author><name sortKey="Ferrero, A" sort="Ferrero, A" uniqKey="Ferrero A" first="A." last="Ferrero">A. 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Hirte</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Juravinski Cancer Centre at Hamilton Health Sciences</s1><s2>Hamilton, Ontario</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Juravinski Cancer Centre at Hamilton Health Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V." last="Gebski">V. 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Friedlander</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Prince of Wales Hospital, Institute of Oncology, High Street, Randwick</s1><s2>Sydney, New South Wales 2031</s2><s3>AUS</s3><sZ>21 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales 2031</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0467462</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0467462 INIST</idno><idno type="RBID">Pascal:11-0467462</idno><idno type="wicri:Area/PascalFrancis/Corpus">001877</idno><idno type="wicri:Area/PascalFrancis/Curation">004679</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001752</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001752</idno><idno type="wicri:doubleKey">0007-0920:2011:Lee C:prognostic:nomogram:to</idno><idno type="wicri:Area/Main/Merge">006C03</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208495</idno><idno type="RBID">PMC:3208495</idno><idno type="wicri:Area/Pmc/Corpus">000092</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000092</idno><idno type="wicri:Area/Pmc/Curation">000092</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000092</idno><idno type="wicri:Area/Pmc/Checkpoint">002197</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002197</idno><idno type="wicri:Area/Ncbi/Merge">000B68</idno><idno type="wicri:Area/Ncbi/Curation">000B68</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B68</idno><idno type="wicri:doubleKey">0007-0920:2011:Lee C:prognostic:nomogram:to</idno><idno type="wicri:Area/Main/Merge">006397</idno><idno type="wicri:Area/Main/Curation">006794</idno><idno type="wicri:Area/Main/Exploration">006794</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer</title><author><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C. K." last="Lee">C. K. Lee</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77</s1><s2>Camperdown, New South Wales 1450</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, New South Wales 1450</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Simes, R J" sort="Simes, R J" uniqKey="Simes R" first="R. J." last="Simes">R. J. Simes</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77</s1><s2>Camperdown, New South Wales 1450</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, New South Wales 1450</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Brown, C" sort="Brown, C" uniqKey="Brown C" first="C." last="Brown">C. Brown</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77</s1><s2>Camperdown, New South Wales 1450</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, New South Wales 1450</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lord, S" sort="Lord, S" uniqKey="Lord S" first="S." last="Lord">S. Lord</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77</s1><s2>Camperdown, New South Wales 1450</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, New South Wales 1450</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Wagner, U" sort="Wagner, U" uniqKey="Wagner U" first="U." last="Wagner">U. Wagner</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Gynecology, Gynecologic Endocrinology and Oncology, University Hospital of Giessen and Marburg</s1><s2>35043 Marburg</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>35043 Marburg</wicri:noRegion><wicri:noRegion>University Hospital of Giessen and Marburg</wicri:noRegion><wicri:noRegion>35043 Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Plante, M" sort="Plante, M" uniqKey="Plante M" first="M." last="Plante">M. Plante</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>CHUQ-Hotel Dieu de Quebec</s1><s2>Quebec City, Quebec</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>CHUQ-Hotel Dieu de Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I." last="Vergote">I. Vergote</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospital Leuven</s1><s2>3000 Leuven</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Pisano, C" sort="Pisano, C" uniqKey="Pisano C" first="C." last="Pisano">C. Pisano</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Medical Oncology B, National Cancer Institute, Via M. Semmola</s1><s2>80131 Napoli</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>80131 Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Parma, G" sort="Parma, G" uniqKey="Parma G" first="G." last="Parma">G. Parma</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Medical Gynecologic Oncology Unit, European Institute of Oncology, Via Ripamonti</s1><s2>435-20141 Milan</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Burges, A" sort="Burges, A" uniqKey="Burges A" first="A." last="Burges">A. Burges</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Gynecology and Obstetrics, Klinikum University of Munic, Campus Grosshadern, Marchioninistr. 15</s1><s2>81337 Munic</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Bourgeois, H" sort="Bourgeois, H" uniqKey="Bourgeois H" first="H." last="Bourgeois">H. Bourgeois</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Onco-Hematology, Centre Jean Bernard - SARL SORECOH, 9 Rue Beauverger</s1><s2>72000 Le Mans</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>72000 Le Mans</wicri:noRegion><wicri:noRegion>9 Rue Beauverger</wicri:noRegion><wicri:noRegion>72000 Le Mans</wicri:noRegion></affiliation></author><author><name sortKey="Hogberg, T" sort="Hogberg, T" uniqKey="Hogberg T" first="T." last="Högberg">T. Högberg</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Gynaecologic Oncology, Linkjoping University Hospital</s1><s2>Linkjoping</s2><s3>SWE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Linkjoping</wicri:noRegion></affiliation></author><author><name sortKey="Bentley, J" sort="Bentley, J" uniqKey="Bentley J" first="J." last="Bentley">J. Bentley</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Dalhousie University, 5820 University Avenue</s1><s2>Halifax, Nova Scotia,B3H IV7</s2><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Halifax, Nova Scotia,B3H IV7</wicri:noRegion></affiliation></author><author><name sortKey="Angleitner Boubenizek, L" sort="Angleitner Boubenizek, L" uniqKey="Angleitner Boubenizek L" first="L." last="Angleitner-Boubenizek">L. Angleitner-Boubenizek</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>BHS Linz, Seilerstätte 4</s1><s2>4020 Linz</s2><s3>AUT</s3><sZ>14 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>4020 Linz</wicri:noRegion></affiliation></author><author><name sortKey="Ferrero, A" sort="Ferrero, A" uniqKey="Ferrero A" first="A." last="Ferrero">A. Ferrero</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Academic Division of Gynecologic Oncology, Mauriziano Hospital</s1><s2>Turin</s2><s3>ITA</s3><sZ>15 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Richter, B" sort="Richter, B" uniqKey="Richter B" first="B." last="Richter">B. Richter</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Gynecology and Obstetrics, University of Dresden</s1><s2>Dresden</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Hirte, H" sort="Hirte, H" uniqKey="Hirte H" first="H." last="Hirte">H. Hirte</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Juravinski Cancer Centre at Hamilton Health Sciences</s1><s2>Hamilton, Ontario</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Juravinski Cancer Centre at Hamilton Health Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V." last="Gebski">V. Gebski</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77</s1><s2>Camperdown, New South Wales 1450</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Camperdown, New South Wales 1450</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Pfisterer, J" sort="Pfisterer, J" uniqKey="Pfisterer J" first="J." last="Pfisterer">J. Pfisterer</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Gynecology, Staedt. Klinikum Solingen, Gotenstr. I</s1><s2>42653 Solingen</s2><s3>DEU</s3><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>42653 Solingen</wicri:noRegion><wicri:noRegion>Gotenstr. I</wicri:noRegion><wicri:noRegion>42653 Solingen</wicri:noRegion></affiliation></author><author><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E." last="Pujade-Lauraine">E. Pujade-Lauraine</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre, Site Hôtel-Dieu, Oncologie, I Place du Parvis Notre-Dame</s1><s2>75004 Paris</s2><s3>FRA</s3><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75004 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M." last="Friedlander">M. Friedlander</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Prince of Wales Hospital, Institute of Oncology, High Street, Randwick</s1><s2>Sydney, New South Wales 2031</s2><s3>AUS</s3><sZ>21 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales 2031</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. J. cancer</title><idno type="ISSN">0007-0920</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of cancer</title><title level="j" type="abbreviated">Br. J. cancer</title><idno type="ISSN">0007-0920</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Human</term><term>Nomogram</term><term>Ovary cancer</term><term>Platinum</term><term>Predictive factor</term><term>Prognosis</term><term>Progression free survival</term><term>Relapse</term><term>Sensitivity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer de l'ovaire</term><term>Pronostic</term><term>Nomogramme</term><term>Facteur prédictif</term><term>Homme</term><term>Platine</term><term>Récidive</term><term>Sensibilité</term><term>Cancérologie</term><term>Survie sans progression</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Platine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy. METHODS: The nomogram was developed in a training cohort (n=955) from the CALYPSO trial and validated in the AGO-OVAR 2.5 Study (n = 340). The proportional-hazards model (nomogram) was based on pre-treatment characteristics. RESULTS: The nomogram had a concordance index (C-index) of 0.645. Significant predictors were tumour size platinum-chemotherapy-free interval, CA-125, number of organ metastatic sites and white blood count. When the nomogram was applied without CA-125 (CA-125 was not available in validation cohort), the C-indices were 0.624 (training) and 0.594 (validation). When classification was based only on the platinum-chemotherapy-free interval, the indices were 0.571 (training) and 0.560 (validation). The calibration plot in the validation cohort based on four predictors (without CA-125) suggested good agreement between actual and nomogram-predicted 12-month PFS probabilities. CONCLUSION This nomogram, using five pre-treatment characteristics, improves prediction of PFS in patients with platinum-sensitive ovarian cancer having platinum-based chemotherapy. It will be useful for the design and stratifcation of patients in clinical trials and also for counselling patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>France</li><li>Italie</li><li>Suède</li></country><region><li>Bavière</li><li>District de Dresde</li><li>District de Haute-Bavière</li><li>Lombardie</li><li>Nouvelle-Galles du Sud</li><li>Piémont</li><li>Province du Brabant flamand</li><li>Saxe (Land)</li><li>Île-de-France</li></region><settlement><li>Dresde</li><li>Louvain</li><li>Milan</li><li>Munich</li><li>Paris</li><li>Sydney</li><li>Turin</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C. K." last="Lee">C. K. Lee</name></region><name sortKey="Brown, C" sort="Brown, C" uniqKey="Brown C" first="C." last="Brown">C. Brown</name><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M." last="Friedlander">M. Friedlander</name><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V." last="Gebski">V. Gebski</name><name sortKey="Lord, S" sort="Lord, S" uniqKey="Lord S" first="S." last="Lord">S. Lord</name><name sortKey="Simes, R J" sort="Simes, R J" uniqKey="Simes R" first="R. J." last="Simes">R. J. Simes</name></country><country name="Allemagne"><noRegion><name sortKey="Wagner, U" sort="Wagner, U" uniqKey="Wagner U" first="U." last="Wagner">U. Wagner</name></noRegion><name sortKey="Burges, A" sort="Burges, A" uniqKey="Burges A" first="A." last="Burges">A. Burges</name><name sortKey="Pfisterer, J" sort="Pfisterer, J" uniqKey="Pfisterer J" first="J." last="Pfisterer">J. Pfisterer</name><name sortKey="Richter, B" sort="Richter, B" uniqKey="Richter B" first="B." last="Richter">B. Richter</name></country><country name="Canada"><noRegion><name sortKey="Plante, M" sort="Plante, M" uniqKey="Plante M" first="M." last="Plante">M. Plante</name></noRegion><name sortKey="Bentley, J" sort="Bentley, J" uniqKey="Bentley J" first="J." last="Bentley">J. Bentley</name><name sortKey="Hirte, H" sort="Hirte, H" uniqKey="Hirte H" first="H." last="Hirte">H. Hirte</name></country><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I." last="Vergote">I. Vergote</name></region></country><country name="Italie"><noRegion><name sortKey="Pisano, C" sort="Pisano, C" uniqKey="Pisano C" first="C." last="Pisano">C. Pisano</name></noRegion><name sortKey="Ferrero, A" sort="Ferrero, A" uniqKey="Ferrero A" first="A." last="Ferrero">A. Ferrero</name><name sortKey="Parma, G" sort="Parma, G" uniqKey="Parma G" first="G." last="Parma">G. Parma</name></country><country name="France"><noRegion><name sortKey="Bourgeois, H" sort="Bourgeois, H" uniqKey="Bourgeois H" first="H." last="Bourgeois">H. Bourgeois</name></noRegion><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E." last="Pujade-Lauraine">E. Pujade-Lauraine</name></country><country name="Suède"><noRegion><name sortKey="Hogberg, T" sort="Hogberg, T" uniqKey="Hogberg T" first="T." last="Högberg">T. Högberg</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Angleitner Boubenizek, L" sort="Angleitner Boubenizek, L" uniqKey="Angleitner Boubenizek L" first="L." last="Angleitner-Boubenizek">L. Angleitner-Boubenizek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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